Abstract: ObjectiveTo estimate HIV high-risk population sizes and the number of people living with HIV/AIDSPLWHAin Jilin province and to provide evidence for HIV prevention and control.MethodsAccording to data of sentinel surveillance,case reporting,epidemiology survey,and scientific lectures,workbook method was used to estimate HIV epidemic in Jilin province.ResultsBy the end of 2009,5668(4262-7075)people were living with HIV/AIDS in Jilin province.The total prevalence of HIV infection was 0.021% (0.016%-0.026%).It is estimated that,among the 5668 PLWHA,43.3% contracted HIV through heterosexual contact,36.6% through homosexual contact,16.7% through blood, 2.9% through injecting drug,and 0.5% through mother to child transmission.ConclusionThe HIV epidemic in Jilin province was still at a lower level in 2009 and the sexual transmission was the main transmission way and HIV infection mainly concentrated in several big cities.