原发性高血压危险因素同胞对病例对照研究

付凌雨; 冯文霄; 时景璞; 李辉; 王海龙; 周波; 王文利; 何磊

doi:10.11847/zgggws2011-27-09-18

原发性高血压危险因素同胞对病例对照研究

Risk factors of essential hypertension：a sib paired case-contorol study

摘要

摘要: 目的探讨在相近的原发性高血压(EH)发病的遗传背景下,环境因素对原发性高血压发生的影响。方法从57户高血压家系中,选取60个年龄相近、性别相同的同胞对,其中一人为原发性高血压患者,另一人为血压正常者,进行1:1配对病例对照研究;应用多因素条件Logistic回归分析筛选原发性高血压的易患危险因素,数据分析采用SPSS 12.0统计软件。结果单因素分析结果显示,吸烟、饮酒、血糖、甘油三酯(TG)、胆固醇(CHOL)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、血钾、血纳、血钙在对照组与病例组之间差异均无统计学意义(P>0.05),仅体质指数(BM I)在对照组与病例组之间差异有统计学意义(P<0.05);多因素条件Logistic回归分析结果显示,BM I可能是原发性高血压的易患危险因素(OR=29.330,95%CI=2.594~331.613)。结论在相近的遗传条件下,BM I可能是原发性高血压的易患危险因素。

Abstract: ObjectiveTo investigate the effect of environmental risk factors on essential hypertension(EH)under the similar genetic background.MethodsThe study selected 60 sibs(one was hypertensive and the other was normotensive) for a paired case-control study.The data were analyzed with mulitple conditional logistic regression using SPSS 12.0 software.ResultsThere was no statistical difference in smoking,drinking,blood fat,blood sugar,serum potassium,serum sodium,serum calcium between hypertensive and normotensive group(P>0.05).The hypertensive individuals had higher body mass index(BMI)than the corresponding normotensive individuals.BMI was a risk factor of EH(P<0.05)with an odds ratio of 29.330(95% confidence interval:2.594-331.613)from multiple conditional logistic regression.ConclusionBMI may be a risk factor of EH under similar genetic background.

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