Abstract: Objective To study the influence of soyasaponins on blood lipid and hemorrheology and its intervention effect on cardiovascular and cerebrovascular diseases in rats.Methods Forty-eight SD healthy male rats were randomly divided into normal control,high fat control,high fat with 10 mg/kg·d of aspirin,high fat with soyasaponins at the doses 20 mg/kg·d,40 mg/kg·d,and 80 mg/kg·d,according to the rats' weight and serum cholesterol level.Ten weeks after the gastric gavage treatment,total cholesterol(TC),triglyceride(TG),high density lipoprotein-cholesterol(HDL-C),lowdensity lipoprotein holesterol(LDL-C),and hemorrheology indexes were determined.Results Compared to high fat control group(2.19 mmol/L),soyasaponins significantly reduced the serum TC(1.86,1.85,and 1.72 mmol/L for groups with 20,40,and 80 mg/kg soyasaponins),LDL-C,TG concentrations and increased the HDL-C levels.Soyasaponins decreased whole blood viscosity(5.13,4.89,and 5.11 mpa·s for groups with 20,40,and 80 mg/kg soyasaponins).The hymatokrit and erythrocyte deformation index increased and the plasma viscosity index,erythrocyte aggregation index and erythrocyte electrophoresis index decreased in soyasaponins treatment groups.Conclusion The results suggest that soyasaponins could adjust blood fat,reduce whole blood viscosity and improve blood viscosity and the effects are beneficial for the prevention of cardiovascular and cerebrovascular diseases.