Abstract: Objective To assess the application time of antibacterials for gynecologic and obstetric patients during peroperative period for rational drug use among the patients.Methods Data of 300 patients undergoing gynecologic or obstetric operation were randomly selected from June 2010 to June 2011 from a first-class hospital at grade 3 in Tianjin.The data of application time of antibacterials was studied retrospectively.Results Fifty-one patients with class I incision and 249 with class II incision had history of antibacterials use during peroperative period with anaverage usage time of 6.7±2.9 days.Of all patients,61 were applied antibacterials at unreasonable time,of which 21.31% without antibacterials before the operation,19.67% with antibacterials 2 hours earlier before the operation,and 14.75% without additive medicine during the operation time longer than 3 hours.Conclusion Management of application time of antibacterials for gynecologic and obstetric patients with surgical operation should be strengthened in the first-class hospital at grade 3 in Tianjin city.