Abstract: Objective To examine therapeutic effect of Chinese medicinal diet on gut derived infection after severe burn in rats.Methods Totally 100 healthy Wistar rats were randomly divided into four groups:the burnal rats with medicinal diet gavage group(medicinal diet group,n=30),the burned rats with bouillon gavage group(bouillon group,n=30),the burned rats with conventional feeding group(conventional group,n=30),and the normal control group(normal group,n=10).At 1,3,7 day after the burn,10 rats in medicinal,bouillon,and conventional group were killed under asepsis condition to detect the pathomorphological change of intestinal mucosa,the intestinal bacteria translocation rate,the endotoxin level,cecum mucosal microflora,and the level of secretory immunoglobulin A(sIgA).Results There were pathomorphological changes in intestinal mucosa of the rats in medicinal diet,bouillon,and conventional group after the burn.The rats in medicinal group recoverd 7 days after the burn,but the rats in bouillon and conventional group didn't completely recoverd.Compared with the normal group,the intestinal bacterial translocation rate,the endotoxin level,the yeast and E.Coli of the rats in medicinal,bouillon,and conventional groups were increased significantly while the level of sIgA and the bifidobacteria were decreased after the burn (P<0.05 or P<0.01).Compared with the medicinal group,the intestinal bacterial translocation rate,the endotoxin level,the yeast and E.Coli of the ras in bouillon and conventional group were increased significantly while the level of sIgA and the bifidobacteria was decreased after the burn (P< 0.05 or P< 0.01).Conclusion Application of traditional Chinese medicinal diet could treat gut derived infection after burn in rats.