Abstract: Objective To explore the geographical distribution and prevalence trend of death caused by road traffic injuries in Guilin city of Guangxi Zhuang Autonomous Region from 2000 to 2009,and to provide scientific evidence for control and prevention of road traffic injury.Methods A distribution map of death caused by road traffic injuries in Guilin city was compiled with inverse distance weighted interpolation method using ArcGIS 9.2,taking the electronic map of Guilin city as a background.Results The map reflected accurately the geographical distribution and prevalence trend of death caused by road traffic injuries in Guilin city.Conclusion The map drawn with inverse distance weighted interpolation method is reliable,convenient,and feasible.