Abstract: Objective To explore the influence factors of road traffic injury among motor vehicle drivers and to provide scientific evidence for road traffic injury prevention and control.Methods The data on road traffic injury(RTI) in Guilin city from 2000 to 2009 were collected and the influence factors of RTI among motor vehicle driver were analyzed with logistic regression.Results There were 3 603 road traffic injuries occured in Guilin city from 2000 to 2009 with 506 people died and 2 911 people injured.The gender ratio for RTI death(men vs women) was 2.54 and the most of RTI casualties were young people aged 21-45 years.There were 3 208 RTI caused by motor vehicle drivers,accounting for 89.04% of the total RTI.Fatigue driving(odds ratioOR=4.280,95% confidence intervalCI:2.055-8.916; P=0.000),over speeding(OR=0.269,95% CI:0.125-0.578; P=0.000),lack of longitudinal space(OR=1.606,95% CI:1.815-3.164; P=0.001),and violation of traffic signal(OR=2.118,95% CI:1.524-2.945; P=0.000) were included the multivaritate conditional logistic regression model.Conclusion Fatigue driving,over speeding,lack of longitudinal space,and violating traffic signal are closely related to the occurrence of road traffic injury.