Abstract: Objective To examine infection status of hepatitis B virus(HBV)and risk factors of HBV infection among Shenzhen residents.Methods With multi-stage cluster systematic random sampling,3 771 residents aged 1-59 years were selected from 1 000 households in 10 communities for a home visiting survey and serological marker test of HBV.Hepatitis B virus surface antigen(HBsAg),antibody to hepatitis B surface antigen(anti-HBs),and antibody of hepatitis B core antigen(anti-HBc)were detected with enzyme-linked immunosorbent assay(ELISA).Results The positive rate of HBsAg,anti-HBs,anti-HBc,and the infection rate of HBV was 6.68%,71.92%,37.39%,and 45.93%,respectively,in the residents.The positive rate of HBsAg and the infection rate of HBV increased with age.Logistic regression analyses showed that the risk factors of HBV infection were with the family member of hepatitis B patients,history of endoscope examination,operation history,and blood donation history.Conclusion The infection rate of HBV in Shenzhen residents was lower than that of the national average rate.HBV infection has the trend of family cluster.Medical and health conditions are major influencing factors of HBV infection.