Abstract: Objective To assess the relationship between alcohol-drinking and chronic diseases among adult inhabitants in Luzhou city.Methods Totally 11 425 adult inhabitants were investigated on their status of alcohol-drinking and the prevalence rate of chronic diseases using the data from Health City Program in Luzhou city,2009.Multiple logistic regression models were employed to explore the relationship between alcohol-drinking and chronic diseases.Results The total prevalence rate of chronic diseases was 24.4% (26.2% for male,22.1% for female)and the total prevalence rate of alcoholdrinking was 13.2% (28.2% for male,1.3% for female).Among 1 505 drinkers,the proportion of drinkers with alcohol consumption of less than 40 g,40-100 g,>100 g for each drinking was 50.9%,40.5%,and 6.1%,respectively.Chi-squre trend tests indicated that the frequency of drinking(χ_trend²=8.305,P=0.004),drinking duration(χ_trend²=101.345,P<0.001),and the total amount alcohol consumption(χ_trend²=17.651,P<0.001)were positively correalated with the prevalence rate of chronic diseases.Multiple logistic regression analyses showed that odds ratio(OR)of chronic disease for the alcohol-drinkers was 0.654(95% confidence interval:0.559-0.766).Conclusion Most inhabitants in Luzhou city had long duration of drinking and frequent drinking history.So related knowledge about the harm of alcohol-drinking should be popularized among residents to reduce the prevalence of chronic diseases among alcohol-drinking residents.