氟砷致骨代谢损伤生物暴露限值基准剂量法分析

Determination of damage in bone metabolism caused by co-exposure to fluoride and arsenic using benchmark dose method in Chinese population

摘要: 目的应用基准剂量法探讨燃煤氟砷污染致暴露人群骨代谢损伤的生物暴露限值,为预防氟砷暴露对人体健康的损害提供骨损害方面的参考依据.方法应用BMDSVersion2.1.2软件计算氟砷暴露人群尿氟、尿砷的基准剂量(BMD)及其可信限下限(BMDL).结果氟、砷混合暴露引起骨代谢损伤的尿氟BMD及BMDL分别为1.96mg/gCr、1.32mg/gCr;尿砷BMD及BMDL分别为120.11μg/gCr、94.83μg/gCr.结论建议氟、砷混合暴露引起暴露人群骨代谢损伤尿氟和尿砷的生物暴露限值分别为1.32mg/gCr和94.83μg/gCr.

Abstract: Objective To explore the biological exposure limitation for bone metabolism injury with benchmark dose method for the determination of potential risk associated with chronic co-exposure to fluoride and arsenic in Chinese population.Methods The benchmark dose(BMD)and the lower confidence limitation for the benchmark dose(BMDL)of urinary fluorine and arsenic in the exposure population were calculated using BMDS Version 2.1.2.Results The BMD and BMDL of urinary fluorine were 1.96 mg/g creatinine and 1.32 mg/g creatinine.BMD and BMDL of urinary arsenic were 120.11μg/g and 94.83μg/g creatinine.Conclusion The estimated biological exposure limitation of urinary fluoride and arsenic were 1.32 mg/g creatinine and 94.83μg/g creatinine in chronic co-exposure to fluoride and arsenic,respectively.