Abstract: Objective To examine the change trend of human resource for laboratory in institutions of disease control and prevention in Shandong province during 2007-2009 and to provide evidence for making human resource plan.Methods A self-designed questionnaire was used to survey all laboratory staff in centers for disease control and prevetion(CDCs)in Shandong province from 2007 to 2009.Results In general,the number and the proportion of laboratory staff were the highest in 2008.The proportion of the staff over the age of 50 years was declined and that of under the age of 40 years was increased.The proportion of the staff with the education under junior college declined and that of with undergraduate or higher education increased from 33.70%(555/1647)to 42.43%(695/1638).The proportion of the staff with senior professional title increased and that of with intermediate title declined year by year.The professional structure of the staff at different administrative levels differed greatly.Conclusion During the three years,the laboratory staff in CDCs in Shandong province were optimized in total number,age distribution,and education level,but there were still some shortcomings as the quantity,title structure and the professional structure should be improved.