Abstract: Objective To explore prevalences and influence factors of anxiety and depression among scientific personnel and to provide reference for psychologitic intervention.Methods A self-administered questionnaire on general condition,Self-Rating Anxiety Scale(SAS),and Self-Rating Depression Scale(SDS)were used to assess 252 scientific personnel.Results The prevalece of anxiety was 20.23% without gender difference(28.13% for males and 22.87% for females)(χ²=0.818,P=0.366).The prevalence of depression was 22.22% without gender difference(30.89% for males and 25.11% for females)(χ²=0.115,P=0.735).The years of working,living condition,and economic pressure had positive correlation with anxiety.Age had a positive correlation with depression.The self reported month income,interpersonal relationship,and the fulfillment of family responsibility had negative correlation with anxiety and depression.Conclusion Scientific personnel have obvious anxiety and depression problems which are affected by various psychological factors.Specific health promotion should be conducted among the personnel.