Abstract: ObjectiveTo explore the difference in intestinal sugar-absorption between diet-induced obesity(DIO) and diet-induced obesity resistance(DR)rats.MethodsThe diet-induced obesity and diet-induced obesity resistance rats models were established by feeding the rats with high-fat diet.Eight weeks after the treatment,the body weight,food intake, and food efficiency were compared between two groups.In addition,8 rats were randomly chosen for oral glucose tolerance test(OGTT)and oral D-xylose tolerance test(OXT).Glucose concentration and serum D-xylose concentration were compared at different time points before and after the administration of gavage.Results Food intake and food efficiency of DIO rats were more than those of DR rats(417.8±33.5 kJ/day vs 379.3±40.2 kJ/day,1.5±0.1×100 g/kJ vs 1.3±0.1×100 g/kJ;P<0.05).Area under the curve of DIO group was more than that of DR group in OGTT (16.5±1.2 mmol/L·h vs 14.6±1.5 mmol/L·h;P<0.05).There was no significant difference between the two groups in the area under the curve for OXT.ConclusionThere are differences in glucose-absorption between high-fat diet-induced obesity and high-fat diet-induced obesity resistant rats,which may play a role in the development of obesity.