Abstract: Objective To examine the willingness,knowledge,and attitude to male circumcision and factors affecting the willingness among non-Muslim male drug users in Xinjiang Uygur Autonomous Region.Methods A cross-sectional questionnaire survey was conducted from January to October 2010 in Urumqi.Results Among 350 representative samples of non-Muslim male drug users,55.1%(193) reported the willingness to take circumcision.The main reasons for the willingness were to improve genital hygiene,to prevent penile cancer,and to treat foreskin or phimosis.Multivariate analyses indicated that those with family member or friends circumcised(odds ratio=2.071,95% confidence intervale:1.043-4.110) and self-judgement of redundant prepuce or phimosis(OR=9.355,95%CI:4.607-18.993)were more likely to take circumcision.Conclusion More than half of non-Muslim male drug users are absolutely willing to take circumcision in the population of Urumqi but the knowledge about male circumcision for human immunodeficiency virus infection prevention should be improved.