Abstract: Objective To explore the prevalence rate and risk factors of reduced renal function(RRF) by retrospective analysis on data from a physical examination sample in Xuzhou city for the prevention of the disorder.Methods Totally 77 355 physical emaminees were selected to estimate glomerular filtration rate(eGFR) by retrospective analysis from 2006-2009.Results The prevalence rate of RRF among the participants was 1.18% with a standardized rate of 1.30%(1.19% for male and 1.18% for female) and there was no significant gender difference in the rate(P>0.05).The prevalence rate of RRF for the participants of 20-,30-,40-,50-,60-,70- and ≥80 age groups was 0.10%,0.20%,0.52%,1.20%,3.30%,7.62%,and 11.58%,respectively,and there were significant differences among the age groups(P=0.000).The prevalence of RRF increased with the increment of age with an increase rate 1.85% per 10 years for the male and 2.18 for the female.The results of logistic regression showed that high plasma viscosity,proteinuria,red blood cell urine,white blood cell urine,high low density lipoprotein,high fasting blood glucose,high systolic blood pressure,and serumuric acid were independently associated with RRF.Conclusion The prevalence rate of RRF in Xuzhou is lower than that of other reports.High plasma viscosity,proteinuria,red blood cell urine,white blood cell urine,high low density lipoprotein,high fasting blood glucose,high systolic blood pressure,and serumuric acid are independently associated with RRF.