Abstract: ObjectiveTo explore the trends and epidemiologic characteristics of syphilis and gonorrhea in Guangdong province based on the data from 1995 to 2010 and to provide scientific basis for further control of the diseases.MethodsRegistered cases of syphilis and gonorrhea in Guangdong provcnce between 1995 to 2010 were collected and were analyzed with epidemiological methods.ResultsFrom 1995 to 2010,the incidence rate of syphilis in Guangdong province increased from 1.78/100 000 to 47.1/100 000,and the incidence rate of latent syphilis increased rapidly.The average increase rate for reported syphilis cases was 38.15%.However,the incidence rate of gonorrhea decreased from 54.51/100 000 in 1995 to 18.51/100 000 in 2010,and the average decrease rate for the reported cases was 4.59%.The reported syphilis and gonorrhea cases were higher among the male,the populations aged 20-30 years,married individuals,and workers.ConclusionDifferent epidemiological characteristics of syphilis and gonorrhea were observed in Guangdong provine and specific and efficient measures should be implemented to control the diseases.