Abstract: ObjectiveTo evaluate the vaccination status of children after implementation of Expanded Immunization Program in Guangdong province and to provide scientific basis for establishing effective strategies.MethodsStratified cluster sampling and probability proportion to size(PPS) procedure were adopted.A total of 6 015 children from 600 administrative villages in 40 counties or urban districts were selected for the survey.ResultsThe qualified innoculation rates for basic immunization of Bacillus Calmette Guerin(BCG),oral poliovirus vaccine(OPV),diphtheria toxoid-pertussis vaccine-tetanus toxoid(DPT),measles vaccine(MV),hepatitis B vaccine(HepB),Japanese encephalitis vaccine(JE),meningococcal polysaccharid vaccine(MPV),and hepatitis A vaccine(HepA) were 99.37%,94.15%,92.59%,90.47%,85.29%,83.09%,70.62%,and 54.34%,respectively.The rate of timely birth dose coverage of HepB was 88.45%.The overall qualified innoculation rate of the six-vaccines including BCG,OPV,DPT,MV,HepB,and JE was 64.74%.The qualified coverage rates on strengthened immunization of DPT,MV and JE were 77.25%,80.8%,and 88.19%,respectively.The qualified coverage rates on basic immunization between different age groups and different census register had no statistically significant difference(P>0.05).However,the qualified innoculation rates on basic immunization of OPV,DPT,MV,HepB,MPV,and HepA in developed areas were higher than those in underdeveloped areas,with statistically significant differences(P<0.05).The unqualified vaccination rates were 0.63 percent to 45.66 percent in Guangdong.The unqualified vaccination rates of HepA was the highest and that of BCG was the lowest.ConclusionThe qualified innoculation rate for basic immunization of BCG,OPV,DPT,MV in Guangdong province maintained at a high level.However,the rates in underdeveloped areas were relatively low.The quality of immunization management in underdeveloped areas should be strengthened.