Abstract: Objective To develop a vision-related quality of life(QOL) scale for adolescent and to evaluate its reliability and validity,and to provide scientific bases for the improvement of quality of life in middle school students with low vision.Methods Document analysis method,panel discussion and questionaire survey were used to develop a vision-related quality of life scale for middle school students.A total of 7 152 students in grade one and grade two from five schools in Wuhan were included in the analyses.Item analysis,exploratory factor analysis,principal component analysis,and determination of reliability and validity were adopted in the analyses.Results With item analysis,exploratory factor analysis,and principal component analysis,22 entries were included in the scale representing four dimensions of physiological function,visual and physical function,social ability,and emotional function.The 22 entries could explain 70.584% of the total variance.The total Cronbach's alpha coefficient and the split-half reliability of the scale were higher than 0.60.The test-retest reliability of the scale ranged from 0.64 to 0.86.Correlation analysis results showed that the correlation coefficient of each dimension and the total score were 0.89,0.80,0.65 and 0.98.The correlation coefficients between the scale scores were 0.56,0.60,0.72,-0.16,-0.11,and -0.19(P＜0.01 for all).Meanwhile,analysis of variance showed that the scores of QOL for students with different vision level were significantly different(P<0.01).Conclusion The vision-related quality of life scale for middle school students was developed and the scale had good reliability and validity.