Abstract: Objective To explore the relationship between serum uric acid level and metabolic syndrome in male and female.Methods A total of 1 173 residents from 4 communities in Yushan and Jingxi district,Kunshan city were selected with cluster random sampling.Data on demographic information,smoking,alcohol consumption,family history of disease were collected and blood pressure,height,weight,waist circumference,blood glucose,blood lipids,and uric acid were detected.Univariate and multivariate logistic regression models were used to evaluate serum uric acid and the metabolic syndrome.Receiver operation characteristic(ROC) curve was used to determine the cut-off point for predicting metabolic syndrome.Results Partial correlation analysis found that serum uric acid level was related to waist circumference,systolic blood pressure,diastolic blood pressure,blood glucose,triglycerides,and high-density lipid chdesterol both in males and females.However,there was no significant relationship between serum uric acid level and blood glucose in males.The risks of the metabolic syndrome increased with serum uric acid levels.Furthermore,there was a dose-response relationship between serum uric acid and the risk of metabolic syndrome.Compared to those with a serum uric acid level <25%,the women with a serum uric acid level of 25%-50% were more likely to have metabolic syndrome(odds ratioOR,95%confidence intervalCI:7.94,2.17-29.0),as well as those with a serum uric acid of >50%(13.2,3.35-51.8).However,we did not find significant association between serum uric acid level and the metabolic syndrome.Additionally,284 μmol/L is the most appropriate cut-off point to diagnose metabolic syndrome in the women.Conclusion Elevated serum uric acid level can be treated as a component of the metabolic syndrome in females.