Abstract: Objective To explore the effectiveness and feasibility of application of school-center for disease control(CDC)-school hospital integrated trinity model for intervention on sexually transmitted disease/acquired immune deficiency syndrome(STD/AIDS) among college students.Methods With stratified cluster sampling method,1 062 second or third year college students majoring in literature and history,chemical industry,art,foreign language,and physical education were selected from Shanxi Datong University,and randomly divided into a intervention group(539) and a control group(539).The intervention group was administered a comprehensive intervention under the trinity model involving school,CDC,and school hospital,and the control group was intervented with expert lectrues.Results After the interventiong,the scores of STD/AIDS knowledge,attitude and behaviors in the intervention group were 40.1?7.5,22.6?6.9,24.1?6.2,higher than the scores before the intervention(29.6?9.9,17.3?9.8,22.9?7.1) with significant differences(P<0.01 for all).After the intervention,the scores for basic knowledge of STD/AIDS,route of transmission,prevention knowledge,social policy were 16.3?3.6,11.6?1.3,8.7?0.6,4.5?0.4 among the intervention group,higher than those of the control group(13.2?6.7,10.5?2.4,7.3?2.6,4.3?0.6) with significant differences(P<0.01 for all).The risk behaviors,including never using condom in sexuall intercourse,exposure to dental or surgery apparatus without strict disinfection,sharing toothbrush or razor with others,scratched by razor in the barber shop,receiving tatto or cosmetology without strict disinfection pocedures,were significantly decreased from 14.9%,5.3%,27.8%,42.3%,12.7%,and 7.2% to 6.2%,2.1%,4.5%,11.2%,5.1%,and 1.9%,respectively,in the intervention groups(P<0.01 for all) Conclusion The school-CDC-school hospital integrated trinity intervention model for STD/AIDS crisis intervention is effective and worth of promotion.