Abstract: ObjectiveTo study the reverse status of gastric precancerous lesions and its influencing factors. MethodsUsing retrospective cohort study,the patients diagnosed as gastric precancerous lesions by pathology in 2004 in Liyang city,Jiangsu province were followed up for 5 years to get the pathological outcome by endoscopy and information on relevant factors were collected with a questionnaire survey. ResultsTotally 41 of 122 patients(33.61%)were reversed from precancerous lesions to non-precancerous lesions.Cox regression analysis showed that after adjustment for age,sex,occupation,smoking,drinking tea and alcohol drinking,compared to non-treatment group,the treatment group had an increased predisposition of reversing precancerous lesions(relative risk RR=3.24;95% confidence interval 95%CI:1.22-8.57).The RR of the reverse for the patients adopting regular medication was 3.92(95%CI:1.45-10.64),the RR of reverse for the patients taking traditional Chinese medication was 5.13(95%CI:1.22-21.74),and the RR for taking western medicine treatment was 2.84(95%CI:1.08-7.46),compared with the unchanged group. ConclusionTaking therapy measures,regular medication may be the important factors to promote gastric precancerous lesions to reverse into the benign outcome.