Abstract: ObjectiveTo evaluate the effect of promotion of male circumcision for HIV/AIDS prevention among male drug users in Guangxi,China.MethodsCluster sampling method was used to recruit 490 HIV/AIDS negative male drug users from four methadone clinics in Guangxi.After a baseline survey,an education program about the knowledge of circumcision to prevent HIV/AIDS was carried out and the subjects who were willing to undergo surgery were provided free circumcision.After nine months,we followed up the subjects to collect the information on the change of their knowledge,willingness and behavior.ResultsAfter the intervention,drug users' willingness for circumcision increased from 56.1% to 66.1% and the rate of surgical circumcision rose from 0% to 22.8%,with statistically significant diffences(P<0.05).The perception of circumcision could prevent HIV/AIDS and other sexually transmitted diseases increased from 29.2% to 70.5%(χ²=160.499,P=0.000)and that of circumcision could protect sexual partners reproductive health increased from 33.7% to 68.1%(χ²=111.148,P=0.000),moreover that of circumcision could prevent genital inflammation or tumors increased from 33.1% to 63.2%(χ²=85.502,P=0.000).ConclusionThe promotion on male circumcision for HIV/AIDS prevention significantly improved the knowledge,willingness and surgery rate of MC in drug users.