Abstract: Objective To explore genetic polymorphisms of cytochrome P4501A1(CYP1A1)and 2EI(CYP2EI),glutathione S-transferase M1(GSTM1)and(GATT1)in relation to human esophageal carcinoma.Methods The genetic polymorphisms of CYP1A1,CYP2E1,GSTM1 and GATT1 in 138 esophageal carcinoma patients and 170 normal controls were detected.Results The genetic polymorphisms of CYP1A1 and GSTT1 were not related to the risk of esophageal carcinoma.The genetic polymorphisms of CYP2E1 and GSTM1 were related to the risk of esophageal carcinoma.The risk of esophageal carcinoma in people with C1 allele was 2.207 times of the people with C2 allele.The risk of esophageal carcinoma in people with C1/C1 allele was 2.256 times of the people with other genotypes.The risk of esophageal carcinoma in people with GSTM1 null was 1.775 times of the people with other genotypes.ConclusionThe genetic polymorphisms of CYP2E1 and GSTM1 are related to human esophageal carcinoma.