Abstract: Objective To analyse epidemiological characteristics and disease burden of road traffic injuries(RTI)in Nanning city from 2000 to 2009,and to provide scientific basis for prevention and control of RTI.Methods The data on RTI in Nanning city were collected from Guangxi Traffic Police Corps and Guangxi Statistics Bureau,and then the epidemiological characteristics,casualties and disease burden of RTI were analyzed.Results The number of RTI was steady from 2000 to 2003,but increased suddenly in 2004(1 038)and went up to the peak in 2005 (1 532).Then the number showed a downward trend from 2005 to 2009.Qingxiu district,Xixiangtang district and Xingning district showed high incidents of RTI,with the total RTI numbers of 1 886,1 578,and 1 432.The male-female ratio of the injuriy and death of RTI was 2.72:1.The deaths occured mainly in the people aged 16 to 50 years,with a number of 1 173,accounting for 71.83% of total deaths in the city.The casualties were mainly caused by incidents of motorcycles,walking,bike,and by car.The main reason of RTI was violating traffic regulations,accounting for 19.7% of all RTI.Years of life lost(YLL)due to RTI in Nanning city from 2000 to 2009 was 39 987.56 person-year,with on economic loss of 260 million RMB yuan.ConclusionThe number of RTI showed a downward trend from 2000 to 2009.But the economic loss due to RTI was serious during the period of 10 years in Nanning city.