Abstract: ObjectiveTo evaluate protective effect of phosphocreatine on myocardial in patients with heart valve replacement surgery.MethodsSixty patients undergoing heart valve replacement surgery were selected and divided randomly into two groups(30 patients in each group).The patients in control group were given St.Thomas cardioplegic solution and those in phosphocreatine-treated group received St.Thomas cardioplegic solution plus phosphocreatine(10 mmol/L).The levels of cardiac troponin-I(cTnI),craetine kinase(CK),and creatine kinase-MB fraction (ck-MB) were measured.ResultsThe serum levels of cTnI and CK were significantly lower in phosphocreatine-treated group than those in the control group 2 hours after the cardiopulmonary bypass operation(all P<0.05),and the levels of cTnI,CK and CK-MB were significantly lower in phosphocreatine-treated group than those in the control group 12 hours after cardiopulmonary bypass operation(all P<0.05).ConclusionPhosphocreatine has significant protective effect on myocardial in patients with heart valve replacement surgery.