Abstract: ObjectiveTo investigate the effect of resveratrol (RSV)on lipid metabolism,liver silent information regulator 1 (SIRT1),and liver X receptor α (LXRα)expression in high-fat diet C57BL/6J mice.MethodsThirty male C57BL/6J mice were divided into control group,high-fat group and intervention group (n=10 for each group);the mice in control group and high-fat diet group were fed with standard or high fat diet,and the mice in intervention group were fed with high fat diet and given RSV by gavage at the same time.After 16 weeks,serum triglyceride(TG),total cholesterol (TC),low density lipoprotein-cholesterol (LDL-C)and high density lipoprotein-cholesterol (HDL-C)levels,and liver TG,TC levels were determined,as well as SIRT1 and LXRα protein levels were measured.ResultsCompared with the control group,the serum TG,TC,and LDL-C levels were 1.25±0.25,4.29±0.59,and 1.59±0.20 mmol/L;liver TG(5.78±1.69 mmol/L)and TC(2.69±1.20 mmol/L)levels in the mice of high fat group were increased,and liver LXRα(0.36±0.03)and SIRT1(0.78±0.07)were decreased(P<0.05).Compared with the high-fat group,serum TG(0.91±0.15 mmol/L),TC(3.65±0.36 mmol/L)and LDL-C(1.39±0.11)in the mice of RSV intervention group and liver TG(4.63±1.70 mmol/L)and TC (1.65±0.89 mmol/L)were decreased significantly,but liver SIRT1(0.41±0.05)and LXRα(0.88± 0.09)increased significantly (P<0.05).ConclusionResveratrol intervention could effectively improve abnormal lipid metabolism in C57BL/6J mice with high fat diet,which may be related to the promotion of liver LXRα and SIRT1 expression.