高级检索

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

高碘诱导甲状腺细胞凋亡机制研究进展

张磊 曾强 刘洪亮

张磊, 曾强, 刘洪亮. 高碘诱导甲状腺细胞凋亡机制研究进展[J]. 中国公共卫生, 2014, 30(4): 534-537. doi: 10.11847/zgggws2014-30-04-51
引用本文: 张磊, 曾强, 刘洪亮. 高碘诱导甲状腺细胞凋亡机制研究进展[J]. 中国公共卫生, 2014, 30(4): 534-537. doi: 10.11847/zgggws2014-30-04-51

高碘诱导甲状腺细胞凋亡机制研究进展

doi: 10.11847/zgggws2014-30-04-51
基金项目: 

国家自然科学基金(30972555);国家自然科学基金(81372934);天津市医药卫生2010年度科技攻关项目(10KG215)

详细信息
    作者简介:

    张磊(1983- ),男,湖北潜江人,主管医师,硕士,主要从事环境与健康研究与管理。

    通信作者:

    刘洪亮,E-mail:liuhongliang@cdctj.gov.cn

  • 中图分类号: R114

  • [1] Zimmermann MB.Iodine deficiency and excess in children:worldwide status in 2013[J].Endocr Pract, 2013, 11:1-27.
    [2] 刘洪亮, 曾强, 韩树清, 等.天津市水源性高碘对小学生甲状腺功能的影响[J].卫生研究, 2007, 36(3):350-352.
    [3] 曹轶, 夏结来, 李婵娟, 等.全民食盐加碘对甲状腺疾病住院构成的影响[J].中国卫生统计, 2012, 29(2):236:237-242.
    [4] Liu XH, Chen GG, Vlantis AC, et al.Iodine mediated mechanisms and thyroid carcinoma[J].Crit Rev Cl Lab Sci, 2009, 46(6):302-318.
    [5] Mahmoud I, Colin I, Many MC, et al.Direct toxic effect of iodide in excess on iodine deficient thyroid glands:epithelial necrosis and inflammation associated with lipofuscin accumulation[J].Exp Mol Pathol, 1986, 44(3):259-271.
    [6] 桑仲娜, 谭龙, 姚斋潇, 等.碘对自身免疫性甲状腺炎大鼠抗氧化能力影响[J].中国公共卫生, 2010, 26(6):723-724.
    [7] Vitale M, Di Matola T, D'Ascoli F, et al.Iodide excess induces apoptosis in thyroid cells through a p53-independent mechanism involving oxidative stress[J].Endocrinology, 2000, 141(2):598-605.
    [8] Hussein AA, Abbas AM, El Wakil GA.Effect of chronic excess iodine intake on thyroid function and oxidative stress in hypothyroid rats[J].Can J Physiol Pharmacol, 2012, 90(5):617-25.
    [9] 张诺, 佟雅洁, 单忠艳.慢性轻中度碘过量对碘缺乏大鼠及非碘缺乏大鼠甲状腺抗氧化能力的影响[J].中华医学杂志, 2006, 86(18):1274-1278.
    [10] Yao X, Li M, He J, et al.Effect of early acute high concentrations of iodide exposure on mitochondrial superoxide production in FRTL cells[J].Free Radical Biology and Medicine, 2012, 52:1343-1352.
    [11] Yu X, Wang L, Acehan D, et al.Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf 21 related killer[J].J Mol Biol, 2006, 355(3):577-589.
    [12] Lehmann P, Rank P, Hallfeldt KL.Dose-related influence of sodium selenite on apoptosis in human thyroid follicles in vitro induced by iodine, EGF, TGF-beta, and H2O2[J].Biol Trace Elem Res, 2006, 112(2):119-130.
    [13] Bossowski A, Czarnocka B, Bardadin K, Analysis of intracellular proapoptotic(Bax, Bak)and antiapoptotic(Bcl-2, Bcl-XL)proteins expression in thyrocytes from young patients with immune and non-immune thyroid disorders[J].Pediatr Endocrinol Diabetes Metab, 2007, 13(2):63-70.
    [14] 刘超, 武晓泓, 覃又文, 等.碘对人甲状腺细胞凋亡的影响[J].中华内分泌代谢杂志, 2001, 17(6):348-349.
    [15] 徐健, 刘小立, 徐秀发, 等.过量碘对甲状腺细胞凋亡的影响[J].卫生研究, 2007, 36(4):443-445.
    [16] 杨长春, 尹桂山, 朱惠民, 等.高碘对甲状腺损伤调控机理的研究[J].中国公共卫生, 2000, 16(12):1113-1114.
    [17] Markovic' L, Todorovic' J, Stankovic' G, et al.Expression of Bcl-2 and Bax proteins in thyroid glands of rats in experimental thyroiditis[J].Folia Biol, 2010, 58(3-4):163-169.
    [18] 李红蔚, 宋岩, 李丽, 等.碘对不同性别大鼠甲状腺细胞凋亡及相关蛋白表达的影响[J].中国体视学与图像分析, 2011, 16(3):323-327.
    [19] Chen W, Man N, Shan Z, et al.Effects of long-term exposure to iodine excess on the apoptosis of thyrocytes in Wistar rats[J].Exp Clin Endocrinol Diabetes, 2011, 119(1):1-8.
    [20] Meldrum DR.Tumor necrosis factor in the heart〔J〕.Am J Physiol, 1998; 274(3-2):577-595.
    [21] Bretz JD, Arscott PL, Myc A, et al.Inflammatory cytokine regulation of Fas-mediated apoptosis in thyroid follicular cells[J].Journal of Biological Chemistry, 1999, 274:25433-25438.
    [22] Giordano C, Stassi G, De Maria R, et al.Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis[J].Science, 1997, 275(5302):960-963.
    [23] 刘东方, 邓华聪, 熊波, 等.高碘诱导甲状腺细胞调亡及其机制研究[J].重庆医科大学学报, 2004, 29(4):425-427.
    [24] 杨帆, 李玉姝, 滕晓春, 等.NOD.H-2h4小鼠自身免疫性甲状腺炎中细胞凋亡及凋亡相关蛋白Fas、Fas-L和FLIP的表达[J].中国医科大学学报, 2009, 38(9):641-643.
    [25] 黄颖泓, 杨立勇, 严孙杰, 等.碘化钠和IL-1对人甲状腺上皮细胞TRAIL表达的影响[J].福建医科大学学报, 2011, 45(5):335-338.
    [26] Yu XJ, Li LY, Li QX.TRAIL and DR5 promote thyroid follicular cell apoptosis in iodine excess-induced experimental autoimmune thyroiditis in NOD mice[J].Biological Trace Element Research, 2011, 43(2):1064-1076.
    [27] 帖丽丽, 张雅萍, 李建虎, 等.高碘增加大鼠甲状腺细胞TRAIL表达[J].中华内分泌代谢杂志, 2006, 22(6):534-536.
    [28] 陈威, 范晨玲, 单忠艳, 等.慢性碘过量增加大鼠甲状腺细胞fas、fasL 和TRAIL 蛋白的表达[J].中国现代医学杂志, 2008, 18(23):3407-3410.2
    [29] 崔玉山, 刘洪亮.碘过量对人甲状腺细胞的损伤作用及机制研究[J].环境与健康杂志, 2012, 29(2):133-135.
    [30] Smerdely P, Pitsiavas V, Boyages SC, et al.Evidence that the inhibitory effects of iodide on thyroid cell proliferation are due to arrest of the cell cycle at G0G1 and G2M phases[J].Endocrinology, 1993, 133:2881-2886.
    [31] Xiao Z, Wang T, Qin H et al.Endoplasmic reticulum Ca2+ release modulates endothelial nitric-oxide synthase via extracellular signal-regulated kinase(ERK)1/2-mediated serine 635 phosphorylation[J].J Biol Chem, 2011, 286(22):20100-20108.
    [32] Ulianich L, Garbi C, Treglia AS, et al.ER stress is associated with dedifferentiation and an epithelial-to-mesenchymal transition-like phenotype in PC Cl3 thyroid cells[J].J Cell Sci, 2008, 121(4):477-486.
    [33] Lee SJ, Kim SH, Kang JG, et al.Effects of all-trans retinoic acid on sodium/iodide symporter and CCAAT/enhancer-binding protein-homologous protein under condition of endoplasmic reticulum stress in FRTL5 thyroid cells[J].Horm Metab Res, 2011, 43:331-336.
    [33] Lee SJ, Kim SH, Kang JG, et al.Effects of all-trans retinoic acid on sodium/iodide symporter and CCAAT/enhancer-binding protein-homologous protein under condition of endoplasmic reticulum stress in FRTL5 thyroid cells[J].Horm Metab Res, 2011, 43:331-336.
    [34] 刘洪亮, 张磊, 曾强, 等.IRE1通路在高碘诱导甲状腺细胞凋亡中的作用[J].环境与健康杂志, 2013, 30(7):137-139.l transition-like phenotype in PC Cl3 thyroid cells[J].J Cell Sci, 2008, 121(4):477-486.
    [34] 刘洪亮, 张磊, 曾强, 等.IRE1通路在高碘诱导甲状腺细胞凋亡中的作用[J].环境与健康杂志, 2013, 30(7):137-139.
  • 加载中
计量
  • 文章访问数:  1112
  • HTML全文浏览量:  165
  • PDF下载量:  78
  • 被引次数: 0
出版历程
  • 接收日期:  2012-11-09
  • 刊出日期:  2014-04-10

目录

    /

    返回文章
    返回