Abstract: Objective To explore the relationship between vitamin D receptor(VDR)genetic polymorphisms and gastric cancer susceptibility and the interaction between VDR and environmental risk factors.Methods A 1:1 matched case-control study was carried out in Nanjing area.Polymerase chain reaction-restriction fragment length polymorphisms(PCR-RFLP)technology was used to determine the genetic polymorphisms of VDR and epidemiology data on environmental exposure were collected.Results The frequencies of VDR-ApaI A and a allele in the case group were 40.60%and 59.40%,while those in the control group were 41.54%and 58.46%,without significant differences between the two groups.The frequencies of VDR-TaqI T and t allele in the case group were 96.90%and 3.10%,while those in the control group were 93.50%and 6.50%,without significant differences between the two groups(χ²=6.676,P<0.05).The frequencies of VDR-ApaI genotype aa,Aa,and AA in the case group were 33.16%,52.48%,and 14.36%,while those in the control group were 29.92%,57.09%,and 12.99%,respectively,without significant differences between the two groups.The frequencies of VDR-TaqI genotypes TT,Tt,and tt in the case group were 91.97%,7.86%,and 0.17%,while those in the control group were 87.35%,12.31%,and 0.34%,respectively,with significant differences between the two groups(χ²=6.757,P<0.05).There were interactions between genotype of VDR and digestive system disease history,family history of tumor,having less fruit,and depression.Conclusion There are associations between VDR poly-morphisms and gastric cancer.