Abstract: Objective To investigate the prevalence and characters of club drug use among undergraduate students in Guangzhou city,and to explore its determinants.Methods A self-administered questionnaire survey was conducted in a cross-sectional study to collect information about illicit drug use behavior,anti-drug education and mental health among 2 411 students from 10 universities selected with stratified cluster randomly sampling.Results The rate of club drug use reached 3.0% (4.6% for males and 1.5% for females).The overall rates of club drug use among the students of minority,having fathers or mothers with education below senior high school,with poor school performance,and receiving first anti-drug education in university were 11.1%,15.2%,8.8%,9.0%,and 12.1%,respectively.Ketamine,cofetol cough syrup,ecstasy and methamphetamine were the most frequently used drugs.The main reasons for the initial drug use were curiosity (35.6%),peer induction (31.5%) and believing specific effect of the drugs (28.8%).The drug use mainly occured in recreational place (52.1%),school (42.5%) and at home (32.9%),respectively.Multivariate logistic regression analyses indicated that the determinants of the drug use were gender (odds ratio OR=0.454),nation (OR=2.744),father's education level (OR=0.243-0.294),the time first receiving anti-drug education (OR=0.310-0.360),and depression (OR=1.073).Conclusion There is a high prevalence of club drug use among undergraduates in Guangzhou city.Males,minority,low education of father,receiving first anti-drug education at late time,and depression could increase the risk of drugs use behavior.