Abstract: Objective To examine the quality of life(QOL) and its influencing factors among discharged schizophrenia patients.Methods Cluster random sampling was adopted to select 215 clinically cured schizophrenia patients who sought return visit at Tangshan Psychiatric Hospital.A self-designed questionnaire,Positive and Negative Syndrome Scale(PANSS),and World Health Organization Quality of Life-BREF(WHOQOL-BREF)were used in the study.Results The average scores of the patients for physiology,psychology,and social relationship domain of QOL were 54.91±15.94,52.69±13.07,and 52.97±19.37,all lower than those of the norm of Chinese(P<0.01),and the average score of environment domain was 50.79±15.96.Among the patients,at the age 36 years or above,living in countryside,with the education of junior middle school or below,and unemployed were inversely related to physiological and social relationship domain of QOL(P<0.05 for all);living in countryside,with the education of junior middle school or below,unmarried or divorced,and unemployed were inversely related to psychological domain of QOL(P<0.05 for all);with a higher score for remained negative symptoms was inversely related to social relationship domain of QOL(P<0.05);and at the age 36 years or above and with the education of junior middle school or below were inversely related to environment domain of QOL(P<0.05).Multiple linear regression analyses showed that main factors affecting QOL of the patients were age,education level,remained negative symptoms,and social rehabilitation.Conclusion The quality of life of schizophrenia patients is poor and is affected by many factors during the period of rehabilitation.