Abstract: Objective To analyze the status of job burnout among the staff in a grassroots center for disease control and prevention,and to explore the relationship between job characteristics and job burnout.Methods A total of 245 staff from a district center for disease control and prevention were investigated with a questionnaire survey using Maslach Burnout Inventory-General Survey(MBI-GS)and a self-designed questionnaire about demographic and job characteristics.Results Among the staff,the overall detection rate of the job burnout was 58.65% and the detection rate of mild,moderate,and severe burnout was 56.56%,32.79%,and 10.66%,respectively;the positive rate of the emotional exhaustion,cynicism,and diminished professional efficacy was 31.73%,31.73%,and 26.92% respectively.There were significant associations between the severity of the job burnout and the item of daily work,the item of temporary work,the proportion of the repetitive job working time (P<0.05 for all).Conclusion Job burnout detection rate was high in the staff in grassroots center for disease control and prevention and the staff suffered from highly exhaustion and cynicism,suggesting that job burnout situation is not optimistic in grassroots center for disease control and prevention.The staff who undertook repetitive work and more work load could suffer from severe job burnout.