Abstract: Objective To explore associations between carcinoembryonic antigen(CEA),carbohydrate antigen 153(CA153),tissue polypeptide specific antigen(TPS) and clinical outcomes in breast cancer patients.Methods A total of 187 female breast cancer patients were selected and followed up.The data on clinical/pathological factors and clinic outcomes were collected and serum CEA,CA153,and TPS were measured among the patients.The relationships between CEA,CA153,TPS level and clinical/pathological factors and survival of the patients were analyzed.Results There were significant differences in positive rates of serum CEA and CA153 among the patients with different tumor-node-metastasis(TNM) stages and between the patients with and without lymph node metastasis(all P<0.05).There were significant differences in the positive rate of TPS among the patients with different TNM stage,lymph node metastasis status,and degree of tumor cell differentiation(all P<0.05).The survival time of the patients with either positive result of CEA/CA153/ TPS or the combination of the three indicators was significantly less than that of the patients with negative result of the indicators(all P<0.05).Cox regression analyses showed that the expression of CA153(risk ratioRR=3.462),TPS(RR=2.193) and degree of cell tumor differentiation(RR=4.215) were independent risk factors for poor prognosis of breast cancer(all P<0.05).Conclusion High serum level of CEA,CA153 and TSP may predict poor outcome for breast cancer patients.CA153,TPS and tumor cell differentiation degree may serve as prognosis factors for breast cancer.