Abstract: Objective To examine spatial distribution of hepatitis A and its influencing factors in Jiangsu province from 2003 to 2009 and to provide basis for making prevention and control measures of hepatitis A.Methods Based on reported data of hepatitis A cases in Jiangsu province from 2003 to 2009,the characteristics of the distribution of hepatitis A and the relevance between hepatitis A prevalence and its influencing factors were analyzed using geographic information system.Results Hepatitis A in the province occurred mainly in the central and southeast of Jiangsu province.The incidence of hepatitis A and the distance from the railway station was negatively correlated.The areas closer to the railway station had higher incidence of hepatitis A.There was a relatively higher incidence of hepatitis A in areas near Hongze Lake and Luoma Lake.Conclusion The incidence of hepatitis A presents a difference in geographical distribution.Efficient preventive and controlling measures for hepatitis A should be taken according to its epidemic strength and influencing factors in different areas.