Abstract: Objective To analyze epidemiological characteristics of hepatitis B in Fujian province and to provide a basis for making prevention and control strategies.Methods The data on hepatitis B prevalence were obtained from National Notifiable Disease Reporting System and analyzed with descriptive and analytic method,with special emphasis on birth cohort description.Results From 2005 to 2012,there were 455 165 cases of hepatitis B reported.The average annual incidence of hepatitis B and acute hepatitis B were 154.21 per 100 000 and 15.39 per 100 000,and the average annual growth rate were 11.66% and 7.30%.The characteristics of prevalence curve by birth cohort of hepatitis B and acute hepatitis B were similar.For the people born between 1949 to 1970,the average annual incidence of hepatitis B and acute hepatitis B fluctuated between 150 to 200 per 100 000 and 10 to 15 per 100 000.For the people born between 1970 to 1990,the prevalence curve of hepatitis B and acute hepatitis B showed single peaks with the highest incidence rate of 284.12 and 38.59 per 100 000.For the people born after 1990,the rates presented a linear decrease.For the people born after 1985,the average annual growth rate of hepatitis B and acute hepatitis B increased faster than in the cohort born before 1985.Conclusion Although the control effect of hepatitis B vaccination and Children Hepatitis B Immunization Program is obvious,the prevalence of hepatitis B in Fujian province is increasing annually.It is necessary to amend the strategy for hepatitis B prevention and control in Fujian province.