Abstract: Objective To assess levels and distribution of job burnout among medical staff in hospitals and health personnel in centers for disease control and prevention(CDC)in Liaoning province.Methods A total of 3 876 medical staff(1 807 doctors,1 405 nurses and 664 CDC staff)in Liaoning province were selected with multistage cluster random sampling to answer a self-designed questionnaire and Maslach Burnout Inventory-General Survey(MBI-GS)Chinese Version.Results The medical staff were scored with 11.1±6.8,5.5±5.3,and 23.0±8.5 for the dimensions of emotional exhaustion,cynicism,and personal accomplishment,respectively.The prevalence rate of low,moderate and high level of job burnout were 29.51%,21.44% and 5.57%,respectively.The prevalence rate of moderate burnout among the nurses(25.05%)was significantly hither than among the doctors(19.81%) and CDC staff(18.22%)(P=0.000).Results of binary logistic regression showed that the prevalence rate of moderate and high level burnout was significantly higher among the staff with the risk factors such as living in urban area,working in tertiary hospitals or city-level CDCs,at the age of 30-39 years,with work experience of 10-19 years,and having higher education or higher professional title(P<0.01 for all).Conclusion Job burnout exists among most medical and CDC staff in Liaoning.Significant differences in burnout exist among the medical staff living in different districts,working in medical fecilities at different levels,and with different job titles.Comprehensive measures should be taken urgently to prevent job burnout among medical staff.