Abstract: Objective To analyze the influence of propofol and isoflurane on anti-inflammation in elderly patients with meningioma.Methods Sixty-five patients of Ⅰ or Ⅱ of American Society of Anaesthesiology(ASA)category and undergoing meningioma surgery were divided randomly into a propofol group(33 patients)and an isoflurane group(32 patients).The patients of propofol group were given intravenous anesthesia with target controlled infusion of propofol 3-6 μg/mL,and those of the isoflurane group received continuous inhalation anesthesia with isoflurane of 1%-2%.Venous blood samples(5 ml for each)of the patients were collected before anesthesia induction and 0,24,and 48 hours after the operation for detections of interleukin 13(IL-13),interleukin 10(IL-10),and interleukin 4(IL-4).Results There were no significant differences in IL-13,IL-10,and IL-4 before anesthesia induction and 0 hour after the operation between propofol and isoflurane group.The serum levels of IL-13,IL-10,and IL-4 were significantly lower in isoflurane group than those in propofol group at 48 hours after the operation(all P<0.05).Conclusion The effect of propofol is better than that of isoflurane in inhibiting inflammatory reaction in elderly patients with meningioma.