Abstract: Objective To study the association between angiotensin-converting enzyme(ACE) gene polymorphism and abnormal savda among Uyghur residents.Methods According to diagnostic standard of Uighur medicine,515 Uygur residents with abnormal savda and 308 with normal helit profile were recruited in Kashgar city of Xinjiang Uygur Autonomous Region.High-resolution melting-PCR(HRM-PCR) method was used to genotype ACE gene.The differences in polymorphisms of 8 sites of ACE gene between the two groups were analyzed.Results For all the participants,the main genotype and allele of ACE gene were AG and A for rs4293 and rs4344,AG and A for rs4303,CT and C for rs4461142,CC and T for rs8075924,CT and T for rs4316818,CC and A for rs1245328 and AG and G,A for rs4353,respectively.The frequencies of genotype GG and allele G in rs4353 and the allele C in rs8075924 were higher in the participants with abnormal savda than in those with normal helit profile(all P<0.01).The frequencies of haploid distribution of AC in rs4461142 and rs4353 were significantly higher in the participants with abnormal savda than in those with normal helit profile(P<0.01).No significant differences in haploid distribution of rs4293,rs4303,rs4344,rs4316818,and rs8075924 were observed between the two groups.Conclusion The ACE gene polymorphisms of rs4353 and AG haplotype of rs4461142 and rs4353 may associate with abnormal savda among Uygur residents.