Abstract: ObjectiveTo explore the attitude towards premarital sex and its influence factors among unmarried females in Luzhou city,Sichuan province,and to provide scientific evidences for reproductive health education.MethodsWith multi-stage random sampling,a self-administered anonymous questionnaire survey was conducted among 2 119 unmarried females aged ≥16 years in Luzhou city.ResultsOf 1 989 participants with valid information,59.83% were not against premarital sex and 24.73% reported premarital sex experience. Multivariate logistic regression analysis showed that the participants at the age of 20-24 and ≥25 years were less likely to oppose premarital sex than those aged ≤20 years old,with the odds ratios(OR)of 0.336(95% confidence interval95%CI=0.211-0.537)and 0.460(95%CI=0.288-0.737);compared with those never receiving sexual education,the participants receiving sexual education frequently and occasionally were less likely to oppose premarital sex,with the OR of 0.472(95%CI=0.289-0.770)and 0.622(95%CI=0.408-0.950);the participants with the knowledge about safe period for contraception were less likely to oppose premarital sex than those without the knowledge,with the OR of 0.611(95%CI=0.472-0.789);the participants having their first menstruation at the age of 13-15 years and ≥ 16 years were more likely to oppose premarital sex than those at the age 10-12 years,with the OR of 2.794(95%CI=1.313-5.949)and 1.636(95%CI=0.783-3.419).ConclusionAge,condition of receiving sexual education,whether having the knowledge about safe period for contraception,and the age at first menstruation are influence factors of attitude towards premarital sex among unmarried females in Luzhou city.