Abstract: ObjectiveTo evaluate the association between two single nucleotide polymorphisms(SNPs)located in RETN gene and type 2 diabetes mellitus(T2DM)in Han population in Guangdong province.MethodsTwo tag SNPs(rs7408174 and rs3219175)were picked out from RETN gene.Then SNP genotyping was performed using SNPscan^TM Kit in 595 cases and 725 controls.Chi-square test,logistic regression model were employed in statistical analyses.ResultsThe frequencies of TT,CT and CC of rs7408174 were 329(55.3%),230(38.7%),and 36(6.1%)in the cases and 366(50.8%),308(42.8%),and 46(6.4%)in the controls,respectively.The frequencies of GG,GA and AA of rs3219175 were 377(63.4%),200(33.6%),and 18(3.0%)in the cases and 442(61.0%),253(34.9%),and 30(4.1%) in the controls,respectively.No association between SNP of rs7408174 and T2DM was found in allelic association analysis and genotypic association analysis after adjustment for sex,body mass index and triglyceride.The other SNP of rs3219175 was not associated with T2DM either.ConclusionNeither rs7408174 nor rs3219175 of RETN gene was associated with T2DM.