Abstract: Objective To explore statuses of mental health and occupational stress and their influencing factors among occupational populations in Karamay municipality of Xinjiang Uygur Autonomous Region(Xinjiang).Methods By using multi-stage cluster random sampling,2 200 employees aged over 18 years(including workers,teachers,military men,civil servants,and medical staff)were selected from Karamay municipality and a questionnaire survey was conducted among the employees with General Health Questionnaire-20(GHQ-20)and Symptom Checklist-90(SCL-90).Results Compared with those of Chinese norm,the employees showed significantly higher SCL-90 scores of obsessive compulsive(1.69±0.58)and phobia(1.36±0.64)but lower scores of somatization(1.33±0.55),interpersonal sensitivity(1.44±0.46),depression(1.42±0.66),and psychoticism(1.23±0.48)(all P <0.001).There were significant differences in SCL-90 total score and all domain scores of among the SCL-90 positive employees with different occupations(all P <0.001).For all the employees,the positive rate of GHQ-20 was 27.5%and the positive rate of SCL-90 was 25.0%and there were significant differences in the two rates among the employees with different occupations(P <0.05),with a high consistency in the screening results of the two scales.Significant difference was observed between the employees with positive and negative result of GHQ-20.Conclusion The occupational stress is relatively serious and the status of mental health is relatively poor among occupational populations in Xinjiang;the results of the survey indicate that effective interventions are needed among the populations.