Abstract: ObjectiveTo investigate the prevalence of muscle fatigue and its related factors among college students in Xi'an city,Shaanxi province.MethodsBy using multi-stage stratified cluster sampling method,1 472 students from 5 universities in Xi'an city were selected for a questionnaire survey on general health condition and muscle fatigue-related symptoms.ResultsThe prevalence of muscle fatigue was 41.8% in the students.The results of logistic regression analysis showed that grade(odds ratioOR=3.184, P=0.038),reading angle(OR=1.012, P=0.006),history of chronic disease(OR=2.026, P=0.009),medication history(OR=2.989, P=0.013),and mental stress(OR=1.457, P<0.001) were related to the increased occurrence of muscle fatigue;whereas,good sleep(OR=0.725, P<0.001)was related to the decreased occurrence of muscle fatigue.The prevalence of muscle fatigue among the students reporting the reading angle of 30° or above was significantly higher than those reporting the reading angle less than 25°(P<0.05).ConclusionThe prevalence of muscle fatigue among college students in Xi'an city is relatively high.Grade,reading angle,history of chronic disease,medication history,mental stress and sleep condition can affect the occurrence of muscle fatigue.