Abstract: ObjectiveTo study quality of life(QOL) and its related factors among personnel working on human immuno-deficiency virus/acquired immunodeficiency syndrome(HIV/AIDS) prevention and control.MethodsTotally 250 AIDS prevention and control personnel from Guangxi Zhuang Autonomous Region(Guangxi) were selected with random cluster sampling and surveyed with World Health Organization's Quality of Life Instrument-Short Version(WHOQOL-BREF).ResultsThe scores of AIDS prevention and control personnel in physical,psychological,social,and environmental domain were lower than those of normal population(P<0.01).The job satisfaction,famliy relationship,and smoking status were the influence factors of physical domain of QOL;job satisfaction,famliy economic conditions were influence factors of psychological domain of QOL;job satisfaction,famliy economic conditions and family relationships were influence factors of social domain of QOL;and job satisfaction,famliy economic conditions and family relationships were influence factors of environmental domain of QOL.ConclusionThe quality of life of AIDS prevention and control personnel in Guangxi are low and job satisfaction,family economic condition and famliy relationship are mian influening factors.