Abstract: ObjectiveTo explore influential factors of diabetic peripheral neuropathy(DPN) and to provide evidences for clinical treatment and prevention of DPN.MethodsFrom May 2012 through May 2014,128 cases of type 2 diabetes were enrolled randomly from the endocrine department of a hospital.The patients were divided into DPN group(51) and non-DPN group(77)according to peripheral neuropathy.The basic clinical data of the cases were collected and compared between two groups to analyze the influential factors of DPN.ResultsThe prevalence of DPN was 39.8% among the 128 patients.Age,duration of diabetes,body mass index(BMI),smoking,physical exercise,systolic blood pressure,fasting plasma glucose(FPG),2-hour postprandial plasma glucose(2hPG),glycosylated hemoglobin(HbA1c),fasting plasma insulin(FINS),2-hour postprandial insulin(2hINS),fasting C peptide(FC-P),and 2-hour postprandial C peptide(2hC-P) were significantly different between the two groups(P<0.05).Multivariate logistic regression analysis revealed that duration of diabetes,smoking,HbA1c,BMI,and 2hPG were positively correlated with DPN prevalence and were independent risk factors of DPN; whereas 2hC-P was negatively correlated with DPN prevalence and was an independent protective factor of DPN.ConclusionThe occurrence of DPN is high in patients with type 2 diabetes.The duration of diabetes,smoking,HbA1c,BMI,2hPG,and 2hC-P are influential factors of DPN.