Abstract: Objective To explore vision-related life quality in the students with different vision level and to provide bases for policy making.Methods Overall 4 096 primary and middle school students were selected from 8 schools with stratified cluster random sampling in an urban and a rural area of Chongqing municipality and surveyed with a vision-related quality of life(QOL) questionnaire.Logarithmic visual acuity chart and subjective refraction were used to examine distant vision and ametropia in the students.Results The rate of poor eyesight was 59.43% and of the students with poor eyesight, 97.91% were myopia.The rate of severe myopia was higher than moderate myopia and the rate of mild myopia was the lowest.The total score of vision-related QOL for the students with normal eyesight was higher than that of the students with low vision(97.71±9.27 vs.86.78±12.76) and the score decreased with the severity of poor sight.Among the students with poor vision, the students with myopia had the lowest scores for vision-related QOL domains of physiological, emotional, social, and overall function(all P=0.00) and the students with hyperopia had the lowest scores for vision-related QOL domains of visual and physical function(all P=0.00).Conclusion The vision-related QOL scores of the students with different vision level are different and appropriate intervention should be taken in the students with different vision problems.