Abstract: Objective To study the status quo of job satisfaction and to explore the mediation effect of coping style on the relationship between perceived stress and job burnout among science and technology professionals(STPs).Methods Totally 2 730 STPs in Zhejiang province were assessed with Maslach Burout Inventory-General Survey(MBI-GS),Perceived Stress Questionnaire,and Trait Coping Style Questionnaire(TCSQ)to evaluate their job burnout,perceived stress level,and coping styles.Results Among the STPs,the domain scores of MBI-GS were 1.90±0.94 for emotional exhaustion,1.38±0.94 for cynicism,and 2.42±1.17 for low sense of achievement;the score of perceived stress was 41.06±16.85;and the TCSQ scores were 33.97±6.75 and 24.63±6.31 for positive and negative response.The positive and negative response played a partial mediation effect on the relationsip between perceived stress and emotional exhaustion and on the relationship between perceived stress and cynicism,with the total effect ratios of 0.154 and 0.170;the positive and negative response also play a complete mediation effect on the relationship between perceived stress and low sence of achievement,with the the total effect ratios of 0.985 and 0.500.Conclusion Coping style plays a mediation effect on the relationship between perceived stress and job burnout among STPs in Zhejiang province.