Abstract: Objective To study the effect of Sacha Inhi oil on blood lipid,apolipoprotein AI(ApoAI),and apolipoprotein B(ApoB)in quails with hyperlipidemia.Methods Hyperlipidemia model was established with high-fat diet feeding in 50 quails and a control group(10 quails)was set with normal diet.Four groups(10 in each group)of hyperlipidmic quails were then administrated with 1.0,0.5,0.25 g/kg Sacha Inhi oil,and perilla oil intragastrically for four weeks and a model group(10 hyperlipidmic quails without further treatment)was set.At the end of the treatments,serum triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),ApoAI,and ApoB were determined and pathologic histology changes in liver were observed with hematoxylin-eosin staining.Results Compared with those of the controls,serum TC(14.23±1.766 mmol/L),TG(2.980±0.384 mmol/L),and LDL-C(8.284±0.727 mmol/L)were significantly higher and serum HDL-C(2.423±0.221 mmol/L)was significantly lower for the quails of model group(all P<0.01).Compared with those of the model group,serum TC(9.50±0.887 and 9.78±1.059 mmol/L),TG (1.662±0.198 and 1.778±0.433 mmol/L),and LDL-C(4.616±0.648 and 5.782±0.863 mmol/L)were significantly lower and serum HDL-C(4.916±0.424 and 4.247±0.702 mmol/L)were significantly higher for the quails in 1.0 and 0.5g/kg Sacha Inchi oil groups(all P<0.05).The level of ApoAI (0.050±0.006 g/L) of the model group was significantly lower than that of the control group(P<0.01),but the level of ApoB (0.110±0.016 g/L)was significantly higher(P<0.01).The level of ApoAI(0.077±0.011 g/L)of the 1.0 g/kg Sacha Inchi oil groups was significantly higher than that of the model group(P<0.05),while the level of ApoB(0.069±0.010 g/L)was significantly lower(P<0.05).Pathological examination revealed serious liver fatty degeneration,with dense areas of fat cavitation in liver cells,for the quails of model and the attenuated liver fatty degeneration was observed in the quails with Sacha Inhi oil of different dosages.Conclusion Sacha Inhi oil can regulate blood lipid in hyperlipidaemic quails and the effect may be related to the improvement of cholesterol metabolism through upregulation of ApoAI and downregulation of ApoB.