Abstract: Objective To study changes in calcium level and related metabolism indicators in obese rats and to provide evidences for the prevention and control of calcium malnutrition induced by obesity.Methods Twenty-five male Wistar rats were randomly divided into a control group(n=10) and an obesity model group(n=15); the rats in the two groups were fed with ordinary feed and high-fat diet,respectively,for 8 weeks and they were sacrificed and their eye blood samples were collected for detections of serum calcium,alkaline phosphatase,parathyroid hormone,calcitonin,calcium-binding protein,and vitamin D receptor.Results Compared with the control group,serum calcium was decreased and alkakine phosphatase increased in obese group significantly(both P<0.05).Compared with the control group,serum parathyroid hormone was increased and calcitonin decreased in obese model group significantly(both P<0.05). Compared with the control group,serum calcium-binding protein was decreased and vitamin D receptor increased in obese model group significantly(both P<0.05).Conclusion Obesity can lead to calcium deficiency and changes in calcium metabolism indices.Obese people should pay attention to the increase of dietary calcium intake.