Abstract: Objective To examine the status of sleep quality and its association with negative life events among medical college students,and to provide evidences for improving sleeping quality of the students.Methods A self-administered questionnaire survey was conducted among 364 students selected from the Shenyang Medical College with stratified sampling.Adolescence Life Events Scale(ASLES)and Pittsburgh Sleep Quality Index(PSQI)questionnaire were used in the study.Results For all the students,20.6% had sleeping problems and the average PSQI score was 5.73 ± 2.46; the incidence of negative life events among the students ranged from 36.81%to 89.01% and the ALSEC score was 34.33± 13.98.The scores of ASLES and PSQI were positively correlated(r=0.270,P<0.001).Results of liner regression analysis showed that higher ASLES score predicted higher PSQI scores(t=5.530,P<0.001).The results of stepwise regression analysis showed that negative life events,such as study pressure,health adaptation,penalty factor,and other factors,could affect the quality of sleep(F=13.039,P=0.000).Conclusion There were a high prevalence of sleep disorders and a negative relationship between negative life events and the quality of sleep among the medical college students.