Abstract: Objective To evaluate the prevalence of post-stroke depression(PSD)among Chinese stroke patients with meta-analysis and to provide references for clinical care of the patients.Methods Literatures search was performed using Chinese Biomedical Data-Base,China National Knowledge Infrastructure,WanFang Database,and VIP Chinese Science and Technology Periodical Database to retrieve studies focused on prevalence of PSD among patients with stroke from Janury 2000 through December 2014.Quality of the included studies was evaluated using Agency for Healthcare Research and Quality(AHRQ)scale.All statistical analysis was conducted with Comprehensive Meta Analysis(CMA)2.0 software.Results Totally 32 articles were included,with 15 834 stroke patients and 5 363 PSD patients involved.The overall prevalence of PSD among the stroke patients was 32.8%(95% confidence interval95% CI:29.5%-36.3%).Subgroup analysis showed that the prevalence of PSD for the patients with left hemisphere only stroke was significantly different from that of non-left hemisphere only stroke(41.7% vs.26.4%,Q=36.5;P<0.01).The prevalence of PSD was affected by the course of stroke,with the prevalence rates of 26.4%,37.6%,and 38.6% for the patients with the stroke within one month,1 to 6 months,and more than 6 months,respectively(Q=9.48,P<0.01).The PSD prevalence rate also varied when evaluated using different scales(Self-Rating Depression ScaleSDS.Hamilton Depression ScaleHAMD:37.7% vs.30.0%,Q=4.96,P=0.03).No statistical differences were observed when the studies were stratified by sex,age,regions and subtype of stroke(with P>0.05).Conclusion The prevalence of PSD is high among Chinese stroke patients.Much attention should be paid to the mental health of stoke patients for improving quality of life of the patients.