SENP蛋白在胶质瘤中表达与临床病理分级相关性

齐玲; 沈楠; 王玮瑶; 赵东海; 杨淑艳; 杨宁江; 王艳春; 任旷

doi:10.11847/zgggws2015-31-09-34

SENP蛋白在胶质瘤中表达与临床病理分级相关性

Expressions of SENP proteins in glioma and its correlation to clinical histological subclassification

摘要

摘要: 目的探讨小泛素样修饰蛋白特异性蛋白酶(SENP)在人脑胶质瘤中的表达变化及与临床病理分级相关性。方法选择神经外科手术切除的脑胶质瘤组织43例作为胶质瘤组,尸解来源的正常脑组织9例作为对照组;Western blot 法检测胶质瘤组与对照组中SENP1、SENP2、SENP6蛋白表达变化,并分析SENP蛋白表达量与患者临床病理分级之间关系。结果胶质瘤组织中SENP1、SENP2、SENP6蛋白表达量分别为(0.47±0.12)、(0.78±0.17)、(0.94±0.21)均明显增加,与对照组分别为(0.35±0.03)、(0.36±0.13)、(0.23±0.08) 比较,差异有统计学意义(均P<0.05);脑胶质瘤组织中SENP1、SENP2、SENP6蛋白表达量与患者临床病理分级呈正相关(r=0.82、0.83、0.91,均P<0.05)。结论胶质瘤组织中SENP蛋白表达明显升高,SENP蛋白表达量与胶质瘤发生发展密切相关。

Abstract: ObjectiveTo explore the change in expressions of small ubiquitin-related modifier-specific proteases(SENP) proteins in glioma and its correlation to clinical histological subclassification.MethodsWe selected 43 cases of glioma surgical resection as glioma group and 9 cases of normal brain tissue obtained from autopsy sources as control group.The change in expressions of SENP1,SENP2,and SENP6 proteins was detected with Western blot and the relationship between the expression of SENP proteins and histological subclassification of glioma was analyzed.ResultsThe expressions of SENP1(0.47±0.12),SENP2(0.78±0.17),and SENP6(0.94±0.21) proteins were significantly increased in glioma tissues compared to those of the control group(0.35±0.03,0.36±0.13,and 0.23±0.08),with statistically significant differences(all P<0.05) and the expression of SENP proteins was positively related to histological subclassification,with the correlation coefficients(r) of 0.82,0.83,and 0.91(all P<0.05).ConclusionThe expression of SENP proteins increases in glioma tissues and closely relates to the development of glioma.

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